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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

紧随其后的是亚马逊创始人杰夫·贝索斯,这是他第一次排名第三,由于亚马逊股值飙升,他的资产达到了728亿美元。
5. Constantly take action.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

Frankly, this is unlikely to be ready in time for next year, but we'll include it just in case. The second film from Laszlo Nemes, who won the foreign language Oscar earlier this year for Son of Saul, is a coming-of-age drama set in Budapest just before the first world war.
The leadership changes across the industry will be of particular interest to female consulting professionals, given none of these firms have ever been run by a woman. Consulting firms are vocal proponents of the business case for improved gender diversity at the top of large companies. It will be interesting to see if any of them decide to practice what they preach.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

“它说明人们看重个人经验,胜过其他可用信息,”库迪斯表示。人们离一个重要事件的中心越远,此事对他们的风险胃口影响就越小。

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

China's economic prowess is also seen by outsiders as having stimulated nationalism in a generation removed from the Cultural Revolution. Beijing's belligerent responses to overlapping maritime claims have heightened worries about its security objectives in a region already wary of its economic clout. This is one factor in Japan's decision to relax its ban on weapons exports; to China's dismay, it has also driven its neighbours to support a stronger US presence in Asia and has complicated regional trade integration.

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

The quickest growth in executive pay on average came from the hotel and catering sectors, at 47.58%.
Chinese tourism to South Korea has boomed in recent years, delighting retailers but irking domestic tourists who have found the country’s attractions swamped with visitors.
Within days of becoming Prime Minister of Great Britain, Winston Churchill (Gary Oldman) must face one of his most turbulent and defining trials: exploring a negotiated peace treaty with Nazi Germany, or standing firm to fight for the ideals, liberty and freedom of a nation.
今年,我最喜欢的人物报道可能是Kiki Zhao对中国目前读者最多的诗人之一余秀华激动人心的描写。余秀华是一个了不起的人。她患有脑瘫,过去41年里大部分时间生活在农村,在一张矮桌子上写作。高中没毕业的她说自己“在能读它们(名著)之前,我就知道如何写作了”。现在,她受邀前往斯坦福大学等地,她不愿被比作艾米丽·迪金森(Emily Dickinson)。

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

Here are our top picks for games that debuted at Gamescom 2014.
2014届大学毕业生工作半年后,平均月收入为3487元,较2013届的3250元、2012届的3048元有了较大增长。
200912/93010.shtml
同时,大批与比特币相关的创业公司于2014年创建,表明比特币势头强劲。我们没有比特币新创企业的详尽名单,但几乎可以肯定的是,2014年成立的比特币新创企业的数量,高于此前任何年份。融资平台AngelList发给《财富》的数据证实了这一点。2011年,5家比特币初创公司在AngelList上登记。2012年,这个数字增加到13家;2013年跃升至193家;2014年更是暴增至566家。【但并非所有创业公司都会(立即)在AngelList上登记。】此外,正如巴里o希尔伯特在推特上所言,1月8日,比特币日交易总量创下历史新高。

Graphical abstract: Trends and targets in antiviral phototherapy
From the themed collection: 2018年北京GDP首破3万亿
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

n. 部分,份,命运,分担的责任

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

"Overall this ranking of Asia's best 300 universities proves what a dynamic, diverse and competitive higher education region the continent is becoming -- and China is a key part of that development," said Baty.

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

2. Mila Kunis
“…was snervous she almost fainted.”

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

北京正努力在年底前完成《区域全面经济伙伴关系协定》(Regional Comprehensive Economic Partnership,简称RCEP)。该协议长期以来被称为中国面对《跨太平洋伙伴关系协定》(Trans-Pacific Partnership agreement,简称TPP)的对策,以及代表了中国争取区域贸易霸权的努力。
中国互联网金融行业继续保持快速增长的节奏。作为国内最大的个人对个人(P2P)网贷平台,陆金所(Lufax)正在寻求10亿美元的新融资,这将使其估值达到150亿至200亿美元。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 南京有银行首套房贷利率上浮25%
Open Access Review Article

Diagnostic technologies for COVID-19: a review

n. 反映,映像,折射,沉思,影响
7. MonPère

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

9. 杰西卡?帕尔
让温馨的祝愿、幸福的思念和友好的祝福,在新年来到你身边,伴你左右。
鉴于计算机编程被冠以“美国经济中尚未开垦的处女地”称号,纽约编程及设计学院正在努力让“谈论”代码变得更简单。到2020年,美国市场上将会有150万个计算机科学相关岗位,而计算机科学专业毕业生则仅有40万人。此外,计算机科学相关岗位在全美的平均增长率是其他职位的两倍。但是如果你并没有计算机科学专业学位,也没有计划重返校园又该如何呢?纽约编程及设计学院通过提供夜校课程和密集型研讨会的方式正在令学习网络设计和开发变得简单——从该项目毕业后,创建一家全新的网站,或是着手寻找技术相关的职位,并不是什么稀罕的事情。正如创始人杰瑞米?司乃帕(Jeremy Snepar)所言,在当下的数字化经济中,你不能不懂得怎样编程。他将编程看做是一种技术能力,一种能够也应该以更为简单的方式学习的能力,而纽约编程及设计学院正是为那些曾经感慨过“如果我懂怎样编程就好了”的人填补了一个重要的空白。
现在基本上只能依靠其他制度(尤其是国会、法庭和媒体)以及公民。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

此次涵盖95个项目(去年为90个)的排行榜中,来自7个国家的9所院校为首次进入榜单。排名第41位的法兰克福金融管理学院(Frankfurt School of Finance & Management)是今年排名最高的新入榜者。这家德国学院拥有性别比例最平衡的项目之一,女性占学员总数的49%。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

在美国监管机构担心交易所交易基金(ETF)市场增速可能太快的同时,他们在亚洲的同行以及资产管理公司和分销商却忙着考虑还有什么办法可以提高投资者的兴趣。
summary

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

“白”之禁忌

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

4. The 2012 Ig Nobel Neuroscience Prize

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

时间:2010-01-29 编辑:vicki
Lei Jun, founder and chairman of Chinese smartphone giant Xiaomi Corp, agreed, describing the win as a breakthrough in artificial intelligence.
节目14 歌曲《报喜》,陈慧琳
如下是我们对中国2014年的10个预测

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

林浩文预测称,市场的任何复苏都将倚赖来自资金充沛的内地公司的需求,同时外国投资者将仅限于投资于房地产投资信托或者涉及地产开发商的股票,而不会真的买入房产。
For those outside the scientific community, the response to the retraction has been mixed.
yacht
[kru:]
It is the continual shrinkage of components that have unleashed the explosion of computing power and enabled these gadgets to be accessible to people across the world.

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

正是由于零部件的不断缩小,这些科技设备的运算效率才得以释放,让它火遍全球。
Best Companies rank: 61

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

明年,市长的保障性住房计划将初具规模,该计划要求在未来十年里,修建或保留20万套保障性住房。这一目标的实现取决于一项政策,它要求开发商通过修建保障性住房,来换取在市政府重新规划的社区修建更高、更密集楼盘的资格。至于政府将会如何在这项提案的雏形上添砖加瓦,开发商和保障房倡导者们都在拭目以待。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
From the themed collection: 家居建材消费投诉升温
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

The mother-to-child transmission rate also reached its historically low point last year, dropping from 7.1 percent in 2012 to 4.9 percent in 2017, Wang said.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

1.哥吃的不是面,是寂寞。
SETTING: This house is on Modena Island, about 20 miles from downtown Savannah. According to the listing agent, the community is gated and has about 20 houses sited amid live oaks and saltwater marshes. Modena Island is a part of Skidaway Island, which has an oceanography research facility operated by the University of Georgia and a large state park.
对中国最大房地产开发商发起敌意收购的神秘亿万富翁姚振华已成为中国最富有的人之一,这凸显出了杠杆金融投资正如何推动私人财富取得巨大增长。
007系列电影主题曲第六名:杜兰·杜兰--《雷霆杀机》

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

8. Julia Roberts - $12 million
自信和出色的“电梯演说”可以提高推销的水平。任何一家公司最早的市场营销经验都来自它的创始人。因此,花时间学习如何分享你的愿景,但不要给人留下“你只是想卖东西”的印象。不要害怕寻求销售机会,但你应该牢牢记住:永远以客户为中心。
The clip, taken on a mobile phone, starts with the crowd singing the Frankie Valli lyrics: You're just too good to be true, can't take my eyes off of you'.
我是一个封闭的人

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

A disturbing and often bleak analysis of the automated future of work has been named 2015’s business book of the year.
献上节日的问候与祝福,愿你拥有一个充满生机和欢乐的新年。

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

A private reading on China's manufacturing sector suggests the slowdown continued last month but that conditions had not worsened as much as in October. The Caixin-sponsored preliminary manufacturing PMI was 48.6 in November, versus expectations of 48.3. It had been 48.3 in October.
In a close second was Changsha, capital of Hunan province, with growth of 4.5.
vigor(n 精力;活力)
Never accept the job immediately. Say you need to think about it overnight. Once you sign on the dotted line there's no room for negotiation.
HEC Paris and London Business School have tightened their grip on the top of the Financial Times rankings of pre-experience and post-experience Masters in Finance programmes respectively, having dominated the finance rankings since they were first published in 2011.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

You think you're so smooth – the James Bond of covert job searching. Where he used wrist-mounted dart guns and camera-implanted rings, you have deceptive "dentist appointments" and a conveniently angled computer monitor to conceal secret résumé tweaking. Unfortunately, while you smugly sip a shaken martini – uh, iced coffee – you may not realize that your cover was blown. Your boss is onto you, and it's no wonder。
但国家统计局认为,CPI上涨的主要原因是去年同期对比基数相对偏低。
而是穆斯克在会上表示,预计特斯拉到2015年底将实现10万台的年产量。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
From the themed collection: 合肥公布租房补贴申请指南
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

比蒂还在台上就遣责了这个因为给错信封而导致的史诗级巨大失误,他说他打开信封就看到了“《爱乐之城》中的爱玛?斯通”的名字。
这个家庭中心内部有三个摄像头,它能够连接到你的手机,你可以通过手机看冰箱里有什么。所以它基本上是一个6000美元替代用纸笔完成购物清单的替代品。

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
From the themed collection: 年轻人,下一站去哪?
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

金融和房地产是国产品牌的支柱,榜单中有38个金融企业,23个房地产企业,占了榜单品牌的30%。
除了这些理论之外,还有传统经济学家用来误导美国的坏的统计数据:最恶劣的是GDP,它在衡量美国长期增长的时候是一个狭窄的、误导人的指标。其次,我们对短期数据(每日收盘情况、季度业绩、年度回报等)的执迷正在阻碍美国的长远增长。
Obama enters his second four-year term faced with a difficult task of tackling $1 trillion annual deficits, reducing a $16 trillion national debt, overhauling expensive social programs and dealing with a gridlocked U.S. Congress that looked likely to maintain the same partisan makeup。

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

7. Cannes' 'year of women' didn't go so well
1.保险精算师
Stanford's Zhenan Baohas has developed a super-flexible, super-durable, and super-sensitive material that can be the basis for future synthetic skin. People have tried developing synthetic skin before, but Baohas's material handles touch sensitivity better than any predecessor. It contains organic transistors and a layer of elastic, letting it stretch without taking damage. And it's self-powered—this skin contains a series of elastic solar cells.

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

她说,“在未来12到24个月,除非这些瓶颈得到解决,否则西得克萨斯中质油价格会跌至每桶50美元,这将促使产油国减产。”

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

日前一份行业报告显示,2016年中国网红预计创造收益高达580亿元,远超2015年中国电影440亿元的票房收入。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

That Apple could launch a 2,000 yuan ($330) iPhone mini and be competitive with flagship products from Lenovo, Huawei, ZTE and Coolpad.
According to the search engine, Euro 2012 beat Olympics tickets as the top internet search of the year in the UK, the Sun reported.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

FlightAware, well known among travelers for its flight tracking app, calculated arrival delays for 18 major and regional U.S. airlines over the Thanksgiving and winter holiday (Christmas through New Year’s) travel periods, as defined by the Transportation Department, from 2010 through 2012.
中国上海——上海这座大都市是中国人口最多的城市,在那里,有着深厚历史底蕴的城市核心区与当代全球金融枢纽融为一体。
特斯拉表示,在该公司的展厅里,每平方英尺的面积带来的销售额是苹果公司(Apple)的两倍,而苹果目前被公认为是行业领军者。
One fifth of the rich in the 500 list are from the information technology industry, and capital players are fading away from the list.

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

2015年9月,当“防止虐待动物协会(RSPCA)”的检察员们打开这处位于南澳大利亚阿德莱德的房子时,他们发现了14只猫咪,其中13只已经死去,仅存的那只也瘦弱不堪。
单词channel 联想记忆:

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

单词commission 联想记忆:
在这6所美国学校中,新泽西的罗格斯商学院(Rutgers Business School)是排名最高的新上榜学校,排名第70。亚利桑那州立大学凯瑞商学院(Arizona State University WP Carey School of Business)是排名最高的重新上榜学校,排在第57位。南卡罗来纳大学(University of South Carolina)摩尔商学院(Moore School of Business)重新上榜,排名第77。摩尔商学院令人瞩目地在国际课程体验排名居首,其学员的海外学习时间从几个月到1年。

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
From the themed collection: 买到“债务问题房”如何维权?
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

5、毕福剑违纪

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

refrigerator
WASHINGTON (MarketWatch) — The U.S. economy finally got a big jolt of energy in 2014 after the lamest recovery since World War II. And 2015 is shaping up to be an even better year.
宣布的
In 1953, Patient HM had experimental brain surgery that left him with striking amnesia. Decades of subsequent research with HM by neuropsychologist Suzanne Corkin made a major contribution to our understanding of memory.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

在主持过去年的奥斯卡颁奖典礼、之前的格莱美奖及艾美奖之后,她无疑是这个角色的最佳选择。
通过药物注射传播艾滋病病毒的情况已得到有效控制。2017年,经注射吸毒感染者的人数相比2012年下降44.5%。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

7.Manage up, down, and sideways
在这6所美国学校中,新泽西的罗格斯商学院(Rutgers Business School)是排名最高的新上榜学校,排名第70。亚利桑那州立大学凯瑞商学院(Arizona State University WP Carey School of Business)是排名最高的重新上榜学校,排在第57位。南卡罗来纳大学(University of South Carolina)摩尔商学院(Moore School of Business)重新上榜,排名第77。摩尔商学院令人瞩目地在国际课程体验排名居首,其学员的海外学习时间从几个月到1年。
自这份年度榜单编制之初,“password”就占据了“最常用密码”的榜首位置。而在2013年榜单中,“password” 排名下滑到了第二位。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

现在的假手除了具备手的外形外,几乎没有其他功能。当然,这些假手能够拿东西和保持身体平衡,但是它们缺乏人手最重要的功能之一——触感。装了假手的人在碰触到一样物品时,如果不用眼睛看,是没法判断东西的。
BROADCHURCH (BBC America, March 4) David Tennant returns in the second season of this evocative British mystery, playing Detective Alec Hardy again (after a season as Detective Emmett Carver in the American remake, “Gracepoint”). With the British premiere scheduled for Monday, the producers have begun to talk a little about the show’s top-secret Season 2 story line, and fans may not like what they hear: Chris Chibnall, the creator and writer, told a British magazine, “It’s not another crime case.” Olivia Colman returns as Detective Ellie Miller, while Charlotte Rampling and Marianne Jean-Baptiste join the cast.
n. 粉底霜,基

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

国内航空统计公司飞常准发布的最新报告显示,我国主要机场的准点率仍然远未让人满意。
adj. 奢侈的,浪费的,过度的,大量的

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
From the themed collection: 美国拟对中国钢材征收256%关税
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

He argues, however, that “US monetary policy is often just as important as domestic factors in explaining the incidence of EM crises, if not more important.”
Instead it ticked upward slightly to 8.3 per cent.
Curry scored 27 points and the defending champions moved within one victory of matching the best start in NBA history, holding off the Chicago Bulls 106-94 on Friday night to improve to 14-0.

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

中国国家旅游局周五发出通知,确认了最近几个月中国游客因所持旅游文件不完整而被拒进入韩国济州岛的报道。该机构提醒中国公民“慎重选择旅游目的地”。
An early iteration of Summly, called Trimit, was featured in Apple's app store in July 2011 on a list of new and noteworthy offerings. There it was noticed by the influential Silicon Valley blog TechCrunch and quickly came to the attention of an investment group led by Li Ka-shing. When D'Aloisio was approached over email by Li's people at Horizons Ventures, he was only 15-and so far mostly managed to conceal that fact. He'd never met with anyone in the tech world face to face, and the information he'd listed when he registered Trimit spoke only vaguely of a London technology company. It failed to mention that the company's management and technology teams-in fact, its entire workforce-consisted of a single kid in a suburban bedroom who wasn't yet old enough to drive.

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

顾伦德.查达哈的这部殖民题材电影讲的是1947年的英印权力移交及其余波。当时蒙巴顿勋爵夫妇的府邸有500名仆人,他们中有印度教徒、穆斯林和锡克教徒。休.博内威利和吉莉安.安德森饰演主人公夫妇。
In this May 6, 1998, file photo, Steve Jobs of Apple Computers unveils the the new iMac computer in Cupertino, Calif
[?'?u?d]

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 长租公寓“野蛮生长”如何规范
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

Switzerland, Sweden and the UK again occupied the top three slots in the ranking. Fifteen of the top 25 economies in the GII come from Europe.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

泰勒·斯威夫特(Taylor Swift),《空白空间》(Blank Space), Big Machine
5. Caterpillar

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

谷歌的品牌价值现在超过了1090亿美元,比苹果公司要高大约20亿美元,这使其成为了全世界最赚钱的公司。
事实上,你要毅然坚决地将工作和找工作划清界限。也就是说,你不能偷偷溜出去接听电话面试。不要浏览找工作的平台。不要用你的工作邮件地址申请和联络。“你不要在工作时看色情照片,同样不要在工作的时候看你的简历,”凯说:“你千万不要。”

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 石材行业如何突破物流“瓶颈”
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

2002年,一名4岁的小男孩患有耳聋,但他不愿意戴助听器,因为超级英雄们都不戴。之后,漫威(Marvel)创作了一个戴着助听器的蓝耳侠(Blue Ear)。
冲击奖项:如果这届奥斯卡最佳影片的提名数有9或10部电影的话,那么《逃出绝命镇》能占一个。乔登皮尔的剧本应该一定会被提名。

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 部分上市公司折价甩卖房产
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

Type D personalities usually have a low self-esteem and a great fear of disapproval and this is the primary reason that prevents them from opening up to others.
The helium pushes the foam upwards through a stencil.

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

中国一群现代汽车经销商要求韩国现代汽车赔偿8-9亿元(1.2-1.35亿美元),称现代汽车削减了向他们出口的车型,导致经销商亏损严重。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

这些数据衡量了校友们自毕业以来在职业方面成就如何,衡量标准包括薪资、职位级别及个人成绩。
Total shipments of cellphones reached 560 million in 2016, up 8% year on year, the report showed.
PC demand has been hit by competition from smartphones and tablets, along with longer lifecycles for PCs. Shipments fell in all regions around the world and have declined for five quarters in a row, according to IDC's figures.
There's a difference, though, in a team like Miami that's playing its young guys and trying to build a core while taking on losses, and, say, the Magic, who are trying to jump-start a stalled process.

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

以下10种妖魔就像无人机一样,瞄准了股市、债市和世界经济:

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 长城民宿惹争议 活化利用要谨慎
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

WTF.1: Next Level of Working Moms
澳大利亚
['pri:dises?]

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Four government agencies including the commerce ministry and the central bank said in December they would apply tighter scrutiny to "irrational" outbound deals including real estate, hotels, movie theatres, entertainment assets and sports clubs.
其中,人们对越野车的热情不减,大约售出了78.49万台,同比飙涨了60.5%,成为车市的贡献最大者。此外,1月份还售出了26.14万台多用途车辆,比去年同期增长15.9%。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
From the themed collection: 2017年建材行业应该注意的几件事
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

adj. 有才能的,有天赋的
新年已至,让我们在此总结一下石油市场形势。实际情况表明,2014年对石油市场来说非常重要——油价在短短六个月内下降了一半。

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

The list features several ineffective passwords that have, for some reason, long maintained their hold among internet users.

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

店长马克·斯特罗恩说,开发这种设备旨在帮助那些忘记自己锁屏密码的iPhone用户进入被锁在手机上的照片或通讯录。斯特罗恩在香港第一次看到这台设备,他表示,在最一开始大家都对其能否起作用持怀疑态度。但随着时间的推移,这台设备一次又一次的证明了自己。
奇才队如果想要留在强队之列,需要尽快给球队动手术。我们已经看到了他们一直以来期待的全员奇才是怎样的水准。
"Perhaps it is no big deal whether or not you are in the group discussion, but if you were absent, 670,000 people would be absent, if you were silent, 670,000 people would be silent."

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
From the themed collection: 超低能耗建筑将成建设新趋势
Paper

Length-scale dependence of protein hydration-shell density

It has exceeded the average level of 2.08% in the EU, while it still lags behind the 2.4% average ratio for member countries of the Organization for Economic Co-operation and Development, the bureau said.
这位工作人员说道:“她注册时说自己姓韩,也不是像媒体上报道的姓苏。”
经销商:经销商们正在努力精简购车的文书手续以及时间。这会使他们留出更多的时间向消费者推销延长质保、喷漆、织物保护、防锈等附加服务。
This slide in the dollar value of exports has entirely been a price effect, driven by lower commodity prices. In volume terms, emerging market exports have continued to rise since 2014, even if volume growth in year-on-year terms has moderated to around 2 per cent, a fraction of the double-digit rates witnessed either side of the global financial crisis, as the second chart shows.

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

“中国银行业面临的逆风将延续很长时间,”他说。“除了盈利来源减少,它们还将不得不为坏账带来的亏损做好准备。”
"I want to tell you what happened I opened the envelope and it said Emma Stone, La La Land and that is why I took such a long look at Faye and at you. I wasn't trying to be funny. This is Moonlight for best picture," Beatty told the shocked crowd as he explained the blunder.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

['kredit]
蓝天和空气一样,对每个人都是平等的。
粮食指数下滑约3%。

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
156 items - Showing page 1 of 3

About this collection

为保证更快的经济增长就必须要要消除美联储所担忧的另一个恶魔:通货紧缩,或者说价格下降。Baumohl 称“经济增长达到3%以上,并且自90年代以来新增了大量工作的国家发生通货紧缩几乎是不可能的”。
项目长度:22个月

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